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The Hormone Shop Monthly Newsletter
June 2003 Volume 6, Issue 6
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Hello:
Welcome to our June 2003, Newsletter. This month we discuss several issues of interest to different groups.
First, you will notice, at the top of the page, we have a new sponsor, "NetZero High Speed". I wanted to know if this new Compression technology really works so I subscribed to it and then tested it using "Speed Tests" for Cable and DSL high speed internet access. What I found was that NetZero High Speed was 5 times faster than my internal dial-up modem !!! It really is 5 times faster than AOL or MSN and it costs only $14.95 per month which is considerable cheaper than either competitor. The down side is that any animated images are distorted and indeed most images are so compressed that they become somewhat distorted. So who wants images? When I use the internet, which is every day, I just want a fast download, good info and I don't need pretty pictures. If this is your need also, then give NetZero a try and I think you will be pleasantly surprised and happy.
We think that from the volume of emails we receive, depression is a pervasive & constant health issue. We have therefore included, this month, an article "DHEA & Depression" and we hope you find this useful and it can help answer some questions.
What's a "Troches"?
Want to test your Neuroregulatory Brain Chemicals? If so, Click here. Why would a Doctor prescribe something to increase Serotonin levels if you already had high levels? Why don't they test first for any deficiency? Beats me, just give them more Prozac or Paxil with no questions asked!
As many of you now know we now sell two new products which are L-Arginine and L-Histidine . Several long-term studies have been performed that show that long term oral administration of L-Arginine or intermittent injection therapy with L-Arginine can improve clinical symptoms of cardiovascular disease in man(1). Since it is the direct precursor of Nitric Oxide (absolutely essential for erections) it should be a part of any supplementation for Erectile Dysfunction in men and/or loss of libido in women and can be a simple solution for several sexually related problems.
L-Histidine is an amino acid which is a vasodilator to help increase blood circulation and a metabolite, histamine, is an absolutely necessity for a sexual climax. Since the body does not produce these two Amino acids you must obtain them from your diet or through supplementation.
Cialis has been such an overwhelming success, thought I'd mention it again. Viagra now has a fantastic competitor called Cialis (pronounced "see-ALL-iss") See above Advertisement on how to purchase from Europe now! It does everything it says it does, can last for days and with fewer side effects. Orders are handled and shipped promptly (from Ireland) from a Doctor and arrive promptly. For more info click here. You can also purchase Generic Viagra® at about half the cost and it is every bit as effective. You can purchase Generic Viagra here.
If you get stuck or have a question, you can call us toll free between the hours of 8:00AM and 8:00Pm Central time. Chances are about 95% that you will get to talk with a real person and not a menu. Remember, we are not doctors and the toll free number is 888-661-3432.
We hope you find this site an interesting place and that it will make your quality of life much higher and your pain and suffering much lower, if so, feel free to recommend it to a friend.
Sincerely & Thanks!
Norman & Brenda Rose
Editors
-
- Pictured here are a pill cutter, which any pharmacy will sell you for little or nothing, a packet of 30 "Troches" (trok - ees) and the slip-on package for the troches. Within the pill cutter is a troche that
has
been easily cut in half. Troches are compounded prescriptions
containing the medicine prescribed by your Doctor in a wax-like
medium. They are easily dissolvable when placed between the cheek and
gum. As you can see this packet contains 30 troches and is the
standard packaging. If your doctor orders Apomorphine HCL, 3mg each,
30 troches, you would cut them in half for a daily dose of 1.5mg and
have a sixty day supply. The cost today would be US$124.50 which is
the same as sublingual tablets the difference being is that you can cut a
troche in half and a small sublingual tablet tends to break up in pieces..
This is the most comvenient method of purchasing Apomorphine HCL or, as it
is called in Europe, "Uprima". This is also the form my wife
purchases for her HRT containing Triest (1.25mg), Progesterone (200mg) and
Testosterone (0.25mg).
There is also a difference in the taste of a sublingual Apomorphine HCL compared to a troche. The troche has a pleasant vanilla taste whereas the sublingual is sort of bitte
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A Replacement Therapy Option for Depression | Purchase USP Pure DHEA |
by ImmuneSupport Staff http://www.ImmuneSupport.com
If you have chronic fatigue syndrome, lupus or fibromyalgia and are suffering from depression consider a natural alternative to prescription anti-depressants: DHEA. Recently the FDA approved DHEA as a drug called "Aslera" to be used in the treatment of Lupus.
DHEA has been shown to improve neurological function (including memory, mood enhancement and EEG readings), immune surveillance and stress disorders. DHEA replacement therapy offers patients help in preventing fatigue and depression.
Supplementing the hormone DHEA restores serum levels to those of a 21-year-old. DHEA is a precursor building block that allows our bodies to more easily create hormones that may be in decline because of age, disease, prescription medications, or other factors.
The most remarkable finding about DHEA came from a human study by S. S. C. Yen and associates at the University of California, San Diego, in which 50 mg a day of DHEA over a 6-month period restored youthful serum levels of DHEA in both men and women. Dr. Yen showed that DHEA replacement was associated with an increase in perceived physical and psychological well-being for both men (67%) and women (84%). Increases in lean body mass and muscle strength were reported in men taking 100 mg a day, but this dose appeared to be excessive in women.
Depression Responds to DHEA Treatment
Reports are stacking up that DHEA works. DHEA turns into both estrogen and testosterone. DHEA is definitely a brain chemical. It's not only utilized by the brain, it's manufactured by it, too. Although researchers don't know what it's supposed to do yet, they do know that giving a person 500 mg of DHEA will cause them to have more REM (dream) sleep. This indicates a major role in brain chemistry.
DHEA is the only hormone besides cortisol that has consistently been linked with depression. It was studied as far back as the 1950s as an antidepressant. Back then, researchers reported that it gave people energy and confidence, and made them less depressed. While it seemed to work great, no one followed up on the studies.
DHEA emerged on the scene again in the 1980s when interest in antiaging hormones geared up. It was noted then that antidepressant activity was part of DHEA's overall antiaging benefits. Then, in 1996, a report suggested that DHEA's antidepressant effects might be direct, and not just a result of its> antiaging benefits in older people. Researchers at Cambridge University discovered that young kids with major depression have abnormally low levels of DHEA (and abnormally high levels of cortisol).
In the late 1990s, this phenomenon was confirmed in a larger study. Researchers at the University of California at San Diego went back and analyzed old data from a large study that had been done on 699 older women living in Rancho Bernardo, California. That analysis is the largest study ever done on the association between levels of DHEA and depression. Nine different hormones had been measured during the study, which took place during the 1970s and 1980s. Included in the measurements were such things as bioavailable testosterone and sex-hormone-binding globulin. When the results were in, of all the hormones, only DHEA was associated with depression. (Low testosterone levels have been correlated with depression in men.)
Women at the lowest end of DHEA were far more likely to be depressed. This coincides with an earlier study where the percentage of women with depression was 21.7% if they had no detectable DHEA, versus 4.6% if DHEA could be detected in their blood. Interestingly, levels of DHEA in the Rancho study correlate with mood even within the normal range. In other words, the lower the DHEA, the worse the mood got. And DHEA correlated with mood irrespective of whether a person was taking antidepressants or not.
A group at the University of California, San Francisco went at the DHEA/depression question another way. They decided to give DHEA to people with depression and see if it would help. In the first double-blind, placebo-controlled study on DHEA's potential as an antidepressant, 11 patients with major depression were given up to 90 mg/day of DHEA for 6 weeks, and 11 were given a placebo. One week before the study actually began, all patients were given a placebo to weed out people who would respond to a sugar pill. People getting the real one received 30 mg a day of DHEA for the first 2 weeks, 60 mg the second 2 weeks, and 90 mg the last 2 weeks. The idea of the graduated dose was to bring patients up to the DHEA levels they had when they were 20 to 30 years old (DHEA declines with age). Although the amount of DHEA wasn't adjusted individually, as it could have> been, the graduated dose approximates what it takes to reach a "youthful"
level in most people, according to Dr. Owen Wolkowitz, principle investigator on the study. Some of the participants were taking antidepressants. For these people, the antidepressants were either working partially, or not working at all. Only people who had been on the same antidepressant for at least 6 weeks without changing were allowed in the study, and no changes could be made in anyone's medication during the study.
After 6 weeks, psychological tests indicated that about half the participants responded to DHEA therapy, with an overall enhancement of mood scores by 30.5%. This is close to the response rate of antidepressant drugs.
An even better response was seen in another study conducted by researchers at the National Institute of Mental Health. In this study, participants were middle-aged people with dysthymia, a chronic, low-grade depression. They were given 90 mg of DHEA a day for 3 weeks, then 450 mg a day for 3 weeks more. Batteries of psychological tests were administered, including the Hamilton Depression Rating Scale, the Beck Depression Inventory, a visual analogue scale, and the Cornell Dysthymia Scale. (In addition, a day's worth of cognitive function tests was given, but DHEA didn't show a significant effect on cognition in this study. However, the researchers note a trend towards better cognition that could have played out if the study had lasted longer). None of the patients were taking any prescription drugs whatsoever except one man, who was taking a hypertension drug. The study was set up in a very rigorous way; all participants got the drug or the placebo for 6 weeks, and then they were all secretly switched. All people involved in the study were blind to who was getting what. DHEA significantly alleviated the participants' depression. Seven symptoms in particular got much better: lack of pleasure, low energy, low motivation, emotional numbness, sadness, inability to cope, and excessive worry. DHEA worked for most people within 10 days. If the supplement was stopped, the symptoms came back. Overall, the response rate was 60%, which is better than what antidepressants usually do for dysthymia. Ninety milligrams a day was sufficient. No extra benefit was provided by the 450 mg dose.
Researchers have different theories about how DHEA alleviates depression. Both DHEA and DHEA-s can cross the blood-brain barrier and interact with the brain directly. DHEA can affect serotonin, GABA receptors, and other brain factors. A recent study indicates it might modulate the serotonin signaling pathway. In addition, DHEA is the precursor for estrogen and testosterone which have been reported to enhance mood.
DHEA also has antistress effects that may be part of its antidepressant action. Research shows that cortisol, the stress hormone, is elevated in major depression. DHEA counteracts cortisol. Calmness appears to be associated with higher levels of DHEA. People who practice transcendental meditation have higher levels of DHEA than those who don't. People who took part in a stress reduction program were able to increase their DHEA by 100%. At the same time, they reduced their stress hormone by 23%.
All of which is good news for those considering a natural treatment option for their depression.
Source:
Life Extension, "DHEA REPLACEMENT
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Spotlight on DHEA:
THE FOLLOWING IS A LIST OF SOME COMMONLY PRESCRIBED NITRATES
If you take one of these medicines
DO NOT TAKE Sildenafil Citrate ( VIAGRA™) or Cialis or any generic
version of the same!
(Note: This is not a comprehensive list. It is not meant to be all-inclusive.)
DRUG & MANUFACTURER of
NITROGLYCERIN containing drugs.
Deponit, Top Nitro
Nitroderm TTS,
Myovin (transdermal) Schwarz Pharma, Inc.
Minitran 3M Pharmaceuticals
Nitrek Bertek Pharameuticals, Inc.
Nitro-Bid Hoechst Marion Roussel
Nitrodisc G.D. Searle Company
Nitro-Dur Key Pharmaceuticals, Inc.
Nitrogard Forest Pharmaceuticals, Inc.
Nitroglyn Kenwood Laboratories
Nitrolingual Spray
GTN Spray Rhone-Poulenc Rorer Pharmaceuticals, Inc.
Nitrol Ointment (Appli-Kit) Savage Laboratories
Nitrong Rhone-Poulenc Rorer Pharmaceuticals, Inc.
Nitro-Par Parmed Pharmaceuticals
Nitrostat Parke-Davis
Nitro-Time Time-Cap Laboratories
Transderm-Nitro Novartis Pharmaceuticals Corporation
ISOSORBIDE MONONITRATE
Monotrate, Vasotrate,
Ismo, Imdur, Angicor
Imdur Key Pharmaceuticals, Inc.
Ismo Wyeth-Ayerst Laboratories
Monoket Tablets Schwarz Pharma, Inc.
ISOSORBIDE DINITRATE
Dilatrate -SR Schwarz Pharma, Inc.
Isordil Wyeth-Ayerst Laboratories
Sorbitrate Zeneca Pharmaceuticals
TRANSDERMAL NITROGLYCERIN PATCHES OR OINTMENTS
Nitroderm TTS, Top Nitro Myovin
ERYTHATYL TETRANITRATE
PENTAERYTHRITOL TETRANITRATE
SODIUM NITROPRUSSIDE
Substances such as amyl nitrate (poppers), which are sometimes abused, should never be combined with Sildenafil Citrate , other Viagra clones, VIAGRA,
Cialis or any generic version of these drugs.
It is however not contradicated with nitrates found in foods.
